Autophagy is to clear aggregated proteins from cells

Autophagy is to clear aggregated proteins from cells, for example in neurodegenerative diseases is important, and it plays a role in cancer and high blood pressure. The IP3 receptor plays an important role in the regulation of programmed cell death, a process , which is reversed in many types of cancer, and neurodegenerative diseases, including Alzheimer's disease and Huntington's. Calcium release from the IP3 receptor at the intersection of neurodegeneration, cancer and the role of cell metabolism have gone awry in these broad disease classes .

The endoplasmic reticulum is the major reservoir of calcium in cells. The stored calcium called to adjacent mitochondria through a calcium ion channel IP3 receptor released. The researchers found that this calcium release occurs at a low level all the time.

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