For short-term use or single dose patients should not exceed 4 grams per day in total.

No evidence-based guidelines exist for the use of analgesics in patients with liver disease and cirrhosis, says Dr. From their findings in the current literature is its recommendation for the long-term use of of acetaminophen in patient with liver cirrhosis for reduced dosing at 2 to 3 grams per day. For short-term use or single dose patients should not exceed 4 grams per day in total, but the proposed new FDA guidelines recommend a maximum daily dose of 2.6 grams per day for anyone.

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